GRB10-MAD1L1 Fusion FISH Probe
The GRB10-MAD1L1 Fusion FISH Probe is used to confirm a fusion of the GRB10 and MAD1L1 genes. The fusion of the GRB10 and MAD1L1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRB10-MAD1L1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-RERE | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-REOR | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-REGO | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-REGR | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-REAQ | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-ORRE | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-OROR | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-ORGO | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GORE | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GOOR | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GOGO | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GOGR | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GRRE | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GROR | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GRGO | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GRGR | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-AQRE | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-AQOR | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-AQGO | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-AQGR | 20 (40 μL) | 200 μL |
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| GRB10-MAD1L1-20-AQAQ | 20 (40 μL) | 200 μL |
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GRB10 Gene Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Gene Name: Growth Factor Receptor Bound Protein 10
Chromosome: CHR7: 50657759 -50861159
Locus: 7p12.1
MAD1L1 Gene Summary
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: Mitotic Arrest Deficient 1 Like 1
Chromosome: CHR7: 1855427 -2272583
Locus: 7p22.3
Gene Diseases
The GRB10 MAD1L1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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