GRB2-PADI1 Fusion FISH Probe
The GRB2-PADI1 Fusion FISH Probe is used to confirm a fusion of the GRB2 and PADI1 genes. The fusion of the GRB2 and PADI1 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRB2-PADI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-RERE | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-REOR | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-REGO | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-REGR | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-REAQ | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-ORRE | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-OROR | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-ORGO | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GORE | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GOOR | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GOGO | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GOGR | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GRRE | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GROR | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GRGO | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GRGR | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-AQRE | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-AQOR | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-AQGO | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-AQGR | 20 (40 μL) | 200 μL |
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| GRB2-PADI1-20-AQAQ | 20 (40 μL) | 200 μL |
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GRB2 Gene Summary
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Growth Factor Receptor Bound Protein 2
Chromosome: CHR17: 73314156 -73401790
Locus: 17q25.1
PADI1 Gene Summary
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Gene Name: Peptidyl Arginine Deiminase 1
Chromosome: CHR1: 17531620 -17572501
Locus: 1p36.13
Gene Diseases
The GRB2 PADI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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