GRB2-TCTEX1D2 Fusion FISH Probe
The GRB2-TCTEX1D2 Fusion FISH Probe is used to confirm a fusion of the GRB2 and TCTEX1D2 genes. The fusion of the GRB2 and TCTEX1D2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GRB2-TCTEX1D2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-RERE | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-REOR | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-REGO | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-REGR | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-REAQ | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-ORRE | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-OROR | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-ORGO | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-ORAQ | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GORE | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GOOR | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GOGO | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GOGR | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GOAQ | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GRRE | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GROR | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GRGO | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GRGR | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-GRAQ | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-AQRE | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-AQOR | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-AQGO | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-AQGR | 20 (40 μL) | 200 μL |
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| GRB2-TCTEX1D2-20-AQAQ | 20 (40 μL) | 200 μL |
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GRB2 Gene Summary
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Growth Factor Receptor Bound Protein 2
Chromosome: CHR17: 73314156 -73401790
Locus: 17q25.1
TCTEX1D2 Gene Summary
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. This gene encodes a subunit of the human cytoplasmic dynein-2 complex. Mutations in this gene are associated with short-rib thoracic dysplasia 17 with or without polydactyly. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Gene Name: Tctex1 Domain Containing 2
Chromosome: CHR3: 196018089 -196045165
Locus: 3q29
Gene Diseases
The GRB2 TCTEX1D2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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