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HEATR5B-MYB Fusion FISH Probe

The HEATR5B-MYB Fusion FISH Probe is used to confirm a fusion of the HEATR5B and MYB genes. The fusion of the HEATR5B and MYB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
HEATR5B-MYB-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
HEATR5B-MYB-20-RERE 20 (40 μL) 200 μL
HEATR5B-MYB-20-REOR 20 (40 μL) 200 μL
HEATR5B-MYB-20-REGO 20 (40 μL) 200 μL
HEATR5B-MYB-20-REGR 20 (40 μL) 200 μL
HEATR5B-MYB-20-REAQ 20 (40 μL) 200 μL
HEATR5B-MYB-20-ORRE 20 (40 μL) 200 μL
HEATR5B-MYB-20-OROR 20 (40 μL) 200 μL
HEATR5B-MYB-20-ORGO 20 (40 μL) 200 μL
HEATR5B-MYB-20-ORAQ 20 (40 μL) 200 μL
HEATR5B-MYB-20-GORE 20 (40 μL) 200 μL
HEATR5B-MYB-20-GOOR 20 (40 μL) 200 μL
HEATR5B-MYB-20-GOGO 20 (40 μL) 200 μL
HEATR5B-MYB-20-GOGR 20 (40 μL) 200 μL
HEATR5B-MYB-20-GOAQ 20 (40 μL) 200 μL
HEATR5B-MYB-20-GRRE 20 (40 μL) 200 μL
HEATR5B-MYB-20-GROR 20 (40 μL) 200 μL
HEATR5B-MYB-20-GRGO 20 (40 μL) 200 μL
HEATR5B-MYB-20-GRGR 20 (40 μL) 200 μL
HEATR5B-MYB-20-GRAQ 20 (40 μL) 200 μL
HEATR5B-MYB-20-AQRE 20 (40 μL) 200 μL
HEATR5B-MYB-20-AQOR 20 (40 μL) 200 μL
HEATR5B-MYB-20-AQGO 20 (40 μL) 200 μL
HEATR5B-MYB-20-AQGR 20 (40 μL) 200 μL
HEATR5B-MYB-20-AQAQ 20 (40 μL) 200 μL

MYB Gene Summary

This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Gene Name: MYB Proto-oncogene, Transcription Factor

Chromosome: CHR6: 135502452 -135540311

Locus: 6q23.3

HEATR5B Gene Summary

The HEAT Repeat Containing 5B (HEATR5B) gene is located on chr2 :37208152-37311485 at 2p22.2.

Gene Name: HEAT Repeat Containing 5B

Chromosome: CHR2: 37208152 -37311485

Locus: 2p22.2

Gene Diseases

The HEATR5B MYB Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland

Adenoid cystic carcinoma (ACC) is a common salivary gland malignancy. The malignancy is associated with gene fusions between MYB, MYBL1, and NFIB. FISH analysis was used to evaluate any rearrangements in these genes with the use of our break apart probes. It was found through FISH that MYB aberrations were preserved between primary tumors and metastases. Additionally, MYB and NFIB aberrations are preserved in ACC metastatic lesions.
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Consistent LEF-1 and MYB Immunohistochemical Expression in Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Potential Diagnostic Pitfall

HPV-related multiphenotypic sinonasal carcinoma (HMSC) is a sinonasal tract neoplasm with a salivary gland tumor-like appearance. The morphologic profile of HMSC is still not fully understood and is under study. One aspect of this morphologic study included FISH analysis with our MYB break apart probes. No rearrangements in MYB were detected by FISH in the cases under study. It was concluded that MYB protein cannot be used to separate adenoid cystic carcinoma from HMSC.
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Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Case Report Documenting the Potential for Very Late Tumor Recurrence

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a tumor of the sinonasal tract with a wide morphologic spectrum. A case study of HMSC was under analysis to contribute more information about it to the literature. In addition to other analyses, FISH was done with our MYB break apart probe. It was concluded that HMSC tumors can have a long-term recurrence as well as indolent behavior.
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MYB rearrangement and immunohistochemical expression in adenomyoepithelioma of the breast: a comparison with adenoid cystic carcinoma

Adenomyoepithelioma (AME) and adenoid cystic carcinoma (ACC) often occur simultaneously, suggesting that AME may be a related or precursor lesion to ACC. MYB gene rearrangements are frequently reported with ACC. Therefore, the rates of MYB rearrangement were compared between AME and ACC. Translocation of the MYB gene was detected by using FISH analysis with our MYB break apart probe. It was concluded that AMEs do not have MYB gene rearrangement.
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