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HERC4-RUFY2 Fusion FISH Probe

The HERC4-RUFY2 Fusion FISH Probe is used to confirm a fusion of the HERC4 and RUFY2 genes. The fusion of the HERC4 and RUFY2 genes has been associated with Breast Invasive Carcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HERC4-RUFY2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
HERC4-RUFY2-20-RERE 20 (40 μL) 200 μL
HERC4-RUFY2-20-REOR 20 (40 μL) 200 μL
HERC4-RUFY2-20-REGO 20 (40 μL) 200 μL
HERC4-RUFY2-20-REGR 20 (40 μL) 200 μL
HERC4-RUFY2-20-REAQ 20 (40 μL) 200 μL
HERC4-RUFY2-20-ORRE 20 (40 μL) 200 μL
HERC4-RUFY2-20-OROR 20 (40 μL) 200 μL
HERC4-RUFY2-20-ORGO 20 (40 μL) 200 μL
HERC4-RUFY2-20-ORAQ 20 (40 μL) 200 μL
HERC4-RUFY2-20-GORE 20 (40 μL) 200 μL
HERC4-RUFY2-20-GOOR 20 (40 μL) 200 μL
HERC4-RUFY2-20-GOGO 20 (40 μL) 200 μL
HERC4-RUFY2-20-GOGR 20 (40 μL) 200 μL
HERC4-RUFY2-20-GOAQ 20 (40 μL) 200 μL
HERC4-RUFY2-20-GRRE 20 (40 μL) 200 μL
HERC4-RUFY2-20-GROR 20 (40 μL) 200 μL
HERC4-RUFY2-20-GRGO 20 (40 μL) 200 μL
HERC4-RUFY2-20-GRGR 20 (40 μL) 200 μL
HERC4-RUFY2-20-GRAQ 20 (40 μL) 200 μL
HERC4-RUFY2-20-AQRE 20 (40 μL) 200 μL
HERC4-RUFY2-20-AQOR 20 (40 μL) 200 μL
HERC4-RUFY2-20-AQGO 20 (40 μL) 200 μL
HERC4-RUFY2-20-AQGR 20 (40 μL) 200 μL
HERC4-RUFY2-20-AQAQ 20 (40 μL) 200 μL

HERC4 Gene Summary

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

Gene Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 4

Chromosome: CHR10: 69681655 -69835103

Locus: 10q21.3

RUFY2 Gene Summary

The RUN And FYVE Domain Containing 2 (RUFY2) gene is located on chr10 :70103274-70166946 at 10q21.3.

Gene Name: RUN And FYVE Domain Containing 2

Chromosome: CHR10: 70103274 -70166946

Locus: 10q21.3

Gene Diseases

The HERC4 RUFY2 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma
Stomach Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.