HEXB-SUPT16H Fusion FISH Probe
The HEXB-SUPT16H Fusion FISH Probe is used to confirm a fusion of the HEXB and SUPT16H genes. The fusion of the HEXB and SUPT16H genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HEXB-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| HEXB-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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HEXB Gene Summary
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Name: Hexosaminidase Subunit Beta
Chromosome: CHR5: 73980968 -74017113
Locus: 5q13.3
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The HEXB SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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