HIST1H2AC-SLC17A4 Fusion FISH Probe
The HIST1H2AC-SLC17A4 Fusion FISH Probe is used to confirm a fusion of the HIST1H2AC and SLC17A4 genes. The fusion of the HIST1H2AC and SLC17A4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HIST1H2AC-SLC17A4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-RERE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-REOR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-REGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-REGR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-REAQ | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-ORRE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-OROR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-ORGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-ORAQ | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GORE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GOOR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GOGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GOGR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GOAQ | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GRRE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GROR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GRGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GRGR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-GRAQ | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-AQRE | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-AQOR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-AQGO | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-AQGR | 20 (40 μL) | 200 μL |
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| HIST1H2AC-SLC17A4-20-AQAQ | 20 (40 μL) | 200 μL |
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HIST1H2AC Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Gene Name: Histone Cluster 1 H2A Family Member C
Chromosome: CHR6: 26124372 -26124918
Locus: 6p22.2
SLC17A4 Gene Summary
Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]
Gene Name: Solute Carrier Family 17 Member 4
Chromosome: CHR6: 25754926 -25781403
Locus: 6p22.2
Gene Diseases
The HIST1H2AC SLC17A4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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