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HLA-B-IQCE Fusion FISH Probe

The HLA-B-IQCE Fusion FISH Probe is used to confirm a fusion of the HLA-B and IQCE genes. The fusion of the HLA-B and IQCE genes has been associated with Uveal Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HLA-B-IQCE-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
HLA-B-IQCE-20-RERE 20 (40 μL) 200 μL
HLA-B-IQCE-20-REOR 20 (40 μL) 200 μL
HLA-B-IQCE-20-REGO 20 (40 μL) 200 μL
HLA-B-IQCE-20-REGR 20 (40 μL) 200 μL
HLA-B-IQCE-20-REAQ 20 (40 μL) 200 μL
HLA-B-IQCE-20-ORRE 20 (40 μL) 200 μL
HLA-B-IQCE-20-OROR 20 (40 μL) 200 μL
HLA-B-IQCE-20-ORGO 20 (40 μL) 200 μL
HLA-B-IQCE-20-ORAQ 20 (40 μL) 200 μL
HLA-B-IQCE-20-GORE 20 (40 μL) 200 μL
HLA-B-IQCE-20-GOOR 20 (40 μL) 200 μL
HLA-B-IQCE-20-GOGO 20 (40 μL) 200 μL
HLA-B-IQCE-20-GOGR 20 (40 μL) 200 μL
HLA-B-IQCE-20-GOAQ 20 (40 μL) 200 μL
HLA-B-IQCE-20-GRRE 20 (40 μL) 200 μL
HLA-B-IQCE-20-GROR 20 (40 μL) 200 μL
HLA-B-IQCE-20-GRGO 20 (40 μL) 200 μL
HLA-B-IQCE-20-GRGR 20 (40 μL) 200 μL
HLA-B-IQCE-20-GRAQ 20 (40 μL) 200 μL
HLA-B-IQCE-20-AQRE 20 (40 μL) 200 μL
HLA-B-IQCE-20-AQOR 20 (40 μL) 200 μL
HLA-B-IQCE-20-AQGO 20 (40 μL) 200 μL
HLA-B-IQCE-20-AQGR 20 (40 μL) 200 μL
HLA-B-IQCE-20-AQAQ 20 (40 μL) 200 μL

HLA-B Gene Summary

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

Gene Name: Major Histocompatibility Complex, Class I, B

Chromosome: CHR6_mcf_hap5: 2701428 -2704782

Locus: 6p21.33

IQCE Gene Summary

The IQ Motif Containing E (IQCE) gene is located on chr7 :2598631-2654368 at 7p22.3.

Gene Name: IQ Motif Containing E

Chromosome: CHR7: 2598631 -2654368

Locus: 7p22.3

Gene Diseases

The HLA-B IQCE Fusion has been associated with the following diseases:

Disease Name
Uveal Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.