HLCS-CD53 Fusion FISH Probe
The HLCS-CD53 Fusion FISH Probe is used to confirm a fusion of the HLCS and CD53 genes. The fusion of the HLCS and CD53 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLCS-CD53-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-RERE | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-REOR | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-REGO | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-REGR | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-REAQ | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-ORRE | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-OROR | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-ORGO | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-ORAQ | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GORE | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GOOR | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GOGO | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GOGR | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GOAQ | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GRRE | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GROR | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GRGO | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GRGR | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-GRAQ | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-AQRE | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-AQOR | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-AQGO | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-AQGR | 20 (40 μL) | 200 μL |
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| HLCS-CD53-20-AQAQ | 20 (40 μL) | 200 μL |
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CD53 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: CD53 Molecule
Chromosome: CHR1: 111413820 -111442558
Locus: 1p13.3
HLCS Gene Summary
This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jun 2011]
Gene Name: Holocarboxylase Synthetase
Chromosome: CHR21: 38123188 -38362545
Locus: 21q22.13
Gene Diseases
The HLCS CD53 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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