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HNRNPH3-KLK1 Fusion FISH Probe

The HNRNPH3-KLK1 Fusion FISH Probe is used to confirm a fusion of the HNRNPH3 and KLK1 genes. The fusion of the HNRNPH3 and KLK1 genes has been associated with Kidney Chromophobe. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HNRNPH3-KLK1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-RERE 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-REOR 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-REGO 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-REGR 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-REAQ 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-ORRE 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-OROR 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-ORGO 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-ORAQ 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GORE 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GOOR 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GOGO 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GOGR 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GOAQ 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GRRE 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GROR 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GRGO 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GRGR 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-GRAQ 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-AQRE 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-AQOR 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-AQGO 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-AQGR 20 (40 μL) 200 μL
HNRNPH3-KLK1-20-AQAQ 20 (40 μL) 200 μL

HNRNPH3 Gene Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]

Gene Name: Heterogeneous Nuclear Ribonucleoprotein H3

Chromosome: CHR10: 70091767 -70102953

Locus: 10q21.3

KLK1 Gene Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]

Gene Name: Kallikrein 1

Chromosome: CHR19: 51322403 -51327043

Locus: 19q13.33

Gene Diseases

The HNRNPH3 KLK1 Fusion has been associated with the following diseases:

Disease Name
Kidney Chromophobe

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.