HNRNPM-DMD Fusion FISH Probe
The HNRNPM-DMD Fusion FISH Probe is used to confirm a fusion of the HNRNPM and DMD genes. The fusion of the HNRNPM and DMD genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HNRNPM-DMD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-RERE | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-REOR | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-REGO | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-REGR | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-REAQ | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-ORRE | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-OROR | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-ORGO | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-ORAQ | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GORE | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GOOR | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GOGO | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GOGR | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GOAQ | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GRRE | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GROR | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GRGO | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GRGR | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-GRAQ | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-AQRE | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-AQOR | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-AQGO | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-AQGR | 20 (40 μL) | 200 μL |
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| HNRNPM-DMD-20-AQAQ | 20 (40 μL) | 200 μL |
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DMD Gene Summary
This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016]
Gene Name: Dystrophin
Chromosome: CHRX: 31137344 -33357726
Locus: Xp21.2-p21.1
HNRNPM Gene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein M
Chromosome: CHR19: 8509802 -8554002
Locus: 19p13.2
Gene Diseases
The HNRNPM DMD Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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