HRH1-TSEN2 Fusion FISH Probe
The HRH1-TSEN2 Fusion FISH Probe is used to confirm a fusion of the HRH1 and TSEN2 genes. The fusion of the HRH1 and TSEN2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HRH1-TSEN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-RERE | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-REOR | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-REGO | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-REGR | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-REAQ | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-ORRE | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-OROR | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-ORGO | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GORE | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GOOR | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GOGO | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GOGR | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GRRE | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GROR | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GRGO | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GRGR | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-AQRE | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-AQOR | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-AQGO | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-AQGR | 20 (40 μL) | 200 μL |
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| HRH1-TSEN2-20-AQAQ | 20 (40 μL) | 200 μL |
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HRH1 Gene Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]
Gene Name: Histamine Receptor H1
Chromosome: CHR3: 11178778 -11304939
Locus: 3p25.3
TSEN2 Gene Summary
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]
Gene Name: TRNA Splicing Endonuclease Subunit 2
Chromosome: CHR3: 12525930 -12574820
Locus: 3p25.2
Gene Diseases
The HRH1 TSEN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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