HS3ST3B1-TMEM92 Fusion FISH Probe
The HS3ST3B1-TMEM92 Fusion FISH Probe is used to confirm a fusion of the HS3ST3B1 and TMEM92 genes. The fusion of the HS3ST3B1 and TMEM92 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HS3ST3B1-TMEM92-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-RERE | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-REOR | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-REGO | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-REGR | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-REAQ | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-ORRE | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-OROR | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-ORGO | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-ORAQ | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GORE | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GOOR | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GOGO | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GOGR | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GOAQ | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GRRE | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GROR | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GRGO | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GRGR | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-GRAQ | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-AQRE | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-AQOR | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-AQGO | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-AQGR | 20 (40 μL) | 200 μL |
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| HS3ST3B1-TMEM92-20-AQAQ | 20 (40 μL) | 200 μL |
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HS3ST3B1 Gene Summary
The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Heparan Sulfate-glucosamine 3-sulfotransferase 3B1
Chromosome: CHR17: 14204505 -14249492
Locus: 17p12
TMEM92 Gene Summary
The Transmembrane Protein 92 (TMEM92) gene is located on chr17 :48348766-48358846 at 17q21.33.
Gene Name: Transmembrane Protein 92
Chromosome: CHR17: 48348766 -48358846
Locus: 17q21.33
Gene Diseases
The HS3ST3B1 TMEM92 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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