HSP90B1-CFB Fusion FISH Probe
The HSP90B1-CFB Fusion FISH Probe is used to confirm a fusion of the HSP90B1 and CFB genes. The fusion of the HSP90B1 and CFB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSP90B1-CFB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-RERE | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-REOR | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-REGO | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-REGR | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-REAQ | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-ORRE | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-OROR | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-ORGO | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GORE | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GOOR | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GOGO | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GOGR | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GRRE | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GROR | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GRGO | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GRGR | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-AQRE | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-AQOR | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-AQGO | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-AQGR | 20 (40 μL) | 200 μL |
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| HSP90B1-CFB-20-AQAQ | 20 (40 μL) | 200 μL |
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CFB Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308 -3205449
Locus: 6p21.33
HSP90B1 Gene Summary
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
Gene Name: Heat Shock Protein 90 Beta Family Member 1
Chromosome: CHR12: 104324188 -104341703
Locus: 12q23.3
Gene Diseases
The HSP90B1 CFB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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