HSPA1B-MYLK Fusion FISH Probe
The HSPA1B-MYLK Fusion FISH Probe is used to confirm a fusion of the HSPA1B and MYLK genes. The fusion of the HSPA1B and MYLK genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPA1B-MYLK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-RERE | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-REOR | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-REGO | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-REGR | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-OROR | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GORE | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GROR | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPA1B-MYLK-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPA1B Gene Summary
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
Gene Name: Heat Shock Protein Family A (Hsp70) Member 1B
Chromosome: CHR6_qbl_hap6: 3089162 -3091686
Locus: 6p21.33
MYLK Gene Summary
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Gene Name: Myosin Light Chain Kinase
Chromosome: CHR3: 123331142 -123603149
Locus: 3q21.1
Gene Diseases
The HSPA1B MYLK Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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