HSPB1-CAMKK2 Fusion FISH Probe
The HSPB1-CAMKK2 Fusion FISH Probe is used to confirm a fusion of the HSPB1 and CAMKK2 genes. The fusion of the HSPB1 and CAMKK2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPB1-CAMKK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-RERE | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-REOR | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-REGO | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-REGR | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-OROR | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GORE | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GROR | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPB1-CAMKK2-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPB1 Gene Summary
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Gene Name: Heat Shock Protein Family B (small) Member 1
Chromosome: CHR7: 75931874 -75933614
Locus: 7q11.23
CAMKK2 Gene Summary
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Gene Name: Calcium/calmodulin Dependent Protein Kinase Kinase 2
Chromosome: CHR12: 121675494 -121736111
Locus: 12q24.31
Gene Diseases
The HSPB1 CAMKK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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