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HSPB1-DDX27 Fusion FISH Probe

The HSPB1-DDX27 Fusion FISH Probe is used to confirm a fusion of the HSPB1 and DDX27 genes. The fusion of the HSPB1 and DDX27 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HSPB1-DDX27-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
HSPB1-DDX27-20-RERE 20 (40 μL) 200 μL
HSPB1-DDX27-20-REOR 20 (40 μL) 200 μL
HSPB1-DDX27-20-REGO 20 (40 μL) 200 μL
HSPB1-DDX27-20-REGR 20 (40 μL) 200 μL
HSPB1-DDX27-20-REAQ 20 (40 μL) 200 μL
HSPB1-DDX27-20-ORRE 20 (40 μL) 200 μL
HSPB1-DDX27-20-OROR 20 (40 μL) 200 μL
HSPB1-DDX27-20-ORGO 20 (40 μL) 200 μL
HSPB1-DDX27-20-ORAQ 20 (40 μL) 200 μL
HSPB1-DDX27-20-GORE 20 (40 μL) 200 μL
HSPB1-DDX27-20-GOOR 20 (40 μL) 200 μL
HSPB1-DDX27-20-GOGO 20 (40 μL) 200 μL
HSPB1-DDX27-20-GOGR 20 (40 μL) 200 μL
HSPB1-DDX27-20-GOAQ 20 (40 μL) 200 μL
HSPB1-DDX27-20-GRRE 20 (40 μL) 200 μL
HSPB1-DDX27-20-GROR 20 (40 μL) 200 μL
HSPB1-DDX27-20-GRGO 20 (40 μL) 200 μL
HSPB1-DDX27-20-GRGR 20 (40 μL) 200 μL
HSPB1-DDX27-20-GRAQ 20 (40 μL) 200 μL
HSPB1-DDX27-20-AQRE 20 (40 μL) 200 μL
HSPB1-DDX27-20-AQOR 20 (40 μL) 200 μL
HSPB1-DDX27-20-AQGO 20 (40 μL) 200 μL
HSPB1-DDX27-20-AQGR 20 (40 μL) 200 μL
HSPB1-DDX27-20-AQAQ 20 (40 μL) 200 μL

HSPB1 Gene Summary

This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

Gene Name: Heat Shock Protein Family B (small) Member 1

Chromosome: CHR7: 75931874 -75933614

Locus: 7q11.23

DDX27 Gene Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]

Gene Name: DEAD-box Helicase 27

Chromosome: CHR20: 47835831 -47860614

Locus: 20q13.13

Gene Diseases

The HSPB1 DDX27 Fusion has been associated with the following diseases:

Disease Name
Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.