HSPG2-SIAE Fusion FISH Probe
The HSPG2-SIAE Fusion FISH Probe is used to confirm a fusion of the HSPG2 and SIAE genes. The fusion of the HSPG2 and SIAE genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HSPG2-SIAE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-RERE | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-REOR | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-REGO | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-REGR | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-REAQ | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-ORRE | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-OROR | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-ORGO | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-ORAQ | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GORE | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GOOR | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GOGO | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GOGR | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GOAQ | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GRRE | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GROR | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GRGO | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GRGR | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-GRAQ | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-AQRE | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-AQOR | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-AQGO | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-AQGR | 20 (40 μL) | 200 μL |
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| HSPG2-SIAE-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPG2 Gene Summary
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Heparan Sulfate Proteoglycan 2
Chromosome: CHR1: 22148736 -22263750
Locus: 1p36.12
SIAE Gene Summary
This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Sialic Acid Acetylesterase
Chromosome: CHR11: 124505684 -124546199
Locus: 11q24.2
Gene Diseases
The HSPG2 SIAE Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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