HTT-WDR19 Fusion FISH Probe
The HTT-WDR19 Fusion FISH Probe is used to confirm a fusion of the HTT and WDR19 genes. The fusion of the HTT and WDR19 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HTT-WDR19-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-RERE | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-REOR | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-REGO | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-REGR | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-OROR | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GORE | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GROR | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| HTT-WDR19-20-AQAQ | 20 (40 μL) | 200 μL |
|
HTT Gene Summary
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2016]
Gene Name: Huntingtin
Chromosome: CHR4: 3076407 -3245687
Locus: 4p16.3
WDR19 Gene Summary
The protein encoded by this gene is a member of the WD (tryptophan-aspartic acid) repeat family, which is a large family of structurally-related proteins known to participate in a wide range of cellular processes. Each WD repeat typically contains about 40 amino acids that are usually bracketed by glycine-histidine and tryptophan-aspartic acid (WD) dipeptides. This protein contains six WD repeats, three transmembrane domains, and a clathrin heavy-chain repeat. Mutations in this gene have been described in individuals with a wide range of disorders affecting function of the cilium. These disorders are known as ciliopathies, and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken syndrome, combined or isolated nephronophthisis (NPHP), and retinitis pigmentosa (RP). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: WD Repeat Domain 19
Chromosome: CHR4: 39184023 -39287430
Locus: 4p14
Gene Diseases
The HTT WDR19 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|