ICA1-HGF Fusion FISH Probe
The ICA1-HGF Fusion FISH Probe is used to confirm a fusion of the ICA1 and HGF genes. The fusion of the ICA1 and HGF genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ICA1-HGF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-RERE | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-REOR | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-REGO | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-REGR | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-REAQ | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-ORRE | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-OROR | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-ORGO | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-ORAQ | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GORE | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GOOR | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GOGO | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GOGR | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GOAQ | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GRRE | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GROR | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GRGO | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GRGR | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-GRAQ | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-AQRE | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-AQOR | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-AQGO | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-AQGR | 20 (40 μL) | 200 μL |
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| ICA1-HGF-20-AQAQ | 20 (40 μL) | 200 μL |
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HGF Gene Summary
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
Gene Name: Hepatocyte Growth Factor
Chromosome: CHR7: 81331443 -81399452
Locus: 7q21.11
ICA1 Gene Summary
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Name: Islet Cell Autoantigen 1
Chromosome: CHR7: 8152814 -8302185
Locus: 7p21.3
Gene Diseases
The ICA1 HGF Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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