ICAM3-TYK2 Fusion FISH Probe
The ICAM3-TYK2 Fusion FISH Probe is used to confirm a fusion of the ICAM3 and TYK2 genes. The fusion of the ICAM3 and TYK2 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ICAM3-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| ICAM3-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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ICAM3 Gene Summary
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Gene Name: Intercellular Adhesion Molecule 3
Chromosome: CHR19: 10444451 -10450345
Locus: 19p13.2
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The ICAM3 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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