IGF2BP3-PRKCA Fusion FISH Probe
The IGF2BP3-PRKCA Fusion FISH Probe is used to confirm a fusion of the IGF2BP3 and PRKCA genes. The fusion of the IGF2BP3 and PRKCA genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGF2BP3-PRKCA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-RERE | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-REOR | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-REGO | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-REGR | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-REAQ | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-ORRE | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-OROR | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-ORGO | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-ORAQ | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GORE | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GOOR | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GOGO | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GOGR | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GOAQ | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GRRE | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GROR | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GRGO | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GRGR | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-GRAQ | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-AQRE | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-AQOR | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-AQGO | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-AQGR | 20 (40 μL) | 200 μL |
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| IGF2BP3-PRKCA-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCA Gene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Alpha
Chromosome: CHR17: 64298925 -64806862
Locus: 17q24.2
IGF2BP3 Gene Summary
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
Gene Name: Insulin Like Growth Factor 2 MRNA Binding Protein 3
Chromosome: CHR7: 23349827 -23509995
Locus: 7p15.3
Gene Diseases
The IGF2BP3 PRKCA Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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