IGFBP3-CLCN3 Fusion FISH Probe
The IGFBP3-CLCN3 Fusion FISH Probe is used to confirm a fusion of the IGFBP3 and CLCN3 genes. The fusion of the IGFBP3 and CLCN3 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGFBP3-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| IGFBP3-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
IGFBP3 Gene Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Insulin Like Growth Factor Binding Protein 3
Chromosome: CHR7: 45951843 -45960871
Locus: 7p12.3
Gene Diseases
The IGFBP3 CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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