IKBKB-FADD Fusion FISH Probe
The IKBKB-FADD Fusion FISH Probe is used to confirm a fusion of the IKBKB and FADD genes. The fusion of the IKBKB and FADD genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IKBKB-FADD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-RERE | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-REOR | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-REGO | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-REGR | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-REAQ | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-ORRE | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-OROR | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-ORGO | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-ORAQ | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GORE | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GOOR | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GOGO | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GOGR | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GOAQ | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GRRE | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GROR | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GRGO | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GRGR | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-GRAQ | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-AQRE | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-AQOR | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-AQGO | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-AQGR | 20 (40 μL) | 200 μL |
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| IKBKB-FADD-20-AQAQ | 20 (40 μL) | 200 μL |
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IKBKB Gene Summary
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta
Chromosome: CHR8: 42128819 -42190171
Locus: 8p11.21
FADD Gene Summary
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Gene Name: Fas Associated Via Death Domain
Chromosome: CHR11: 70049268 -70053508
Locus: 11q13.3
Gene Diseases
The IKBKB FADD Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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