IKBKG-GAB3 Fusion FISH Probe
The IKBKG-GAB3 Fusion FISH Probe is used to confirm a fusion of the IKBKG and GAB3 genes. The fusion of the IKBKG and GAB3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IKBKG-GAB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-RERE | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-REOR | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-REGO | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-REGR | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-REAQ | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-ORRE | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-OROR | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-ORGO | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GORE | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GOOR | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GOGO | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GOGR | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GRRE | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GROR | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GRGO | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GRGR | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-AQRE | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-AQOR | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-AQGO | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-AQGR | 20 (40 μL) | 200 μL |
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| IKBKG-GAB3-20-AQAQ | 20 (40 μL) | 200 μL |
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IKBKG Gene Summary
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]
Gene Name: Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Gamma
Chromosome: CHRX: 153770458 -153793261
Locus: Xq28
GAB3 Gene Summary
This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: GRB2 Associated Binding Protein 3
Chromosome: CHRX: 153903526 -153979348
Locus: Xq28
Gene Diseases
The IKBKG GAB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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