IL17RA-SCARF2 Fusion FISH Probe
The IL17RA-SCARF2 Fusion FISH Probe is used to confirm a fusion of the IL17RA and SCARF2 genes. The fusion of the IL17RA and SCARF2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IL17RA-SCARF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-RERE | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-REOR | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-REGO | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-REGR | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-REAQ | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-ORRE | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-OROR | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-ORGO | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GORE | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GOOR | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GOGO | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GOGR | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GRRE | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GROR | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GRGO | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GRGR | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-AQRE | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-AQOR | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-AQGO | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-AQGR | 20 (40 μL) | 200 μL |
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| IL17RA-SCARF2-20-AQAQ | 20 (40 μL) | 200 μL |
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IL17RA Gene Summary
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
Gene Name: Interleukin 17 Receptor A
Chromosome: CHR22: 17565850 -17596584
Locus: 22q11.1
SCARF2 Gene Summary
The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Scavenger Receptor Class F Member 2
Chromosome: CHR22: 20778873 -20792146
Locus: 22q11.21
Gene Diseases
The IL17RA SCARF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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