IL17RC-TTLL3 Fusion FISH Probe
The IL17RC-TTLL3 Fusion FISH Probe is used to confirm a fusion of the IL17RC and TTLL3 genes. The fusion of the IL17RC and TTLL3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IL17RC-TTLL3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-RERE | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-REOR | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-REGO | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-REGR | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-REAQ | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-ORRE | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-OROR | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-ORGO | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-ORAQ | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GORE | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GOOR | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GOGO | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GOGR | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GOAQ | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GRRE | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GROR | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GRGO | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GRGR | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-GRAQ | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-AQRE | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-AQOR | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-AQGO | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-AQGR | 20 (40 μL) | 200 μL |
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| IL17RC-TTLL3-20-AQAQ | 20 (40 μL) | 200 μL |
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TTLL3 Gene Summary
The Tubulin Tyrosine Ligase Like 3 (TTLL3) gene is located on chr3 :9851643-9878040 at 3p25.3.
Gene Name: Tubulin Tyrosine Ligase Like 3
Chromosome: CHR3: 9851643 -9878040
Locus: 3p25.3
IL17RC Gene Summary
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
Gene Name: Interleukin 17 Receptor C
Chromosome: CHR3: 9958757 -9975305
Locus: 3p25.3-p24.1
Gene Diseases
The IL17RC TTLL3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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