IL18R1-MCOLN2 Fusion FISH Probe
The IL18R1-MCOLN2 Fusion FISH Probe is used to confirm a fusion of the IL18R1 and MCOLN2 genes. The fusion of the IL18R1 and MCOLN2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IL18R1-MCOLN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-RERE | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-REOR | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-REGO | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-REGR | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-REAQ | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-ORRE | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-OROR | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-ORGO | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GORE | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GOOR | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GOGO | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GOGR | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GRRE | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GROR | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GRGO | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GRGR | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-AQRE | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-AQOR | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-AQGO | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-AQGR | 20 (40 μL) | 200 μL |
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| IL18R1-MCOLN2-20-AQAQ | 20 (40 μL) | 200 μL |
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IL18R1 Gene Summary
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Name: Interleukin 18 Receptor 1
Chromosome: CHR2: 102979096 -103015217
Locus: 2q12.1
MCOLN2 Gene Summary
Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]
Gene Name: Mucolipin 2
Chromosome: CHR1: 85391265 -85462796
Locus: 1p22.3
Gene Diseases
The IL18R1 MCOLN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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