IL4R-NSMCE1 Fusion FISH Probe
The IL4R-NSMCE1 Fusion FISH Probe is used to confirm a fusion of the IL4R and NSMCE1 genes. The fusion of the IL4R and NSMCE1 genes has been associated with Skin Cutaneous Melanoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IL4R-NSMCE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-RERE | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-REOR | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-REGO | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-REGR | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-REAQ | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-ORRE | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-OROR | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-ORGO | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GORE | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GOOR | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GOGO | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GOGR | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GRRE | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GROR | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GRGO | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GRGR | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-AQRE | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-AQOR | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-AQGO | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-AQGR | 20 (40 μL) | 200 μL |
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| IL4R-NSMCE1-20-AQAQ | 20 (40 μL) | 200 μL |
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IL4R Gene Summary
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Gene Name: Interleukin 4 Receptor
Chromosome: CHR16: 27325250 -27376099
Locus: 16p12.1
NSMCE1 Gene Summary
The NSE1 Homolog, SMC5-SMC6 Complex Component (NSMCE1) gene is located on chr16 :27236314-27280113 at 16p12.1.
Gene Name: NSE1 Homolog, SMC5-SMC6 Complex Component
Chromosome: CHR16: 27236314 -27280113
Locus: 16p12.1
Gene Diseases
The IL4R NSMCE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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