IL6ST-DDX4 Fusion FISH Probe
The IL6ST-DDX4 Fusion FISH Probe is used to confirm a fusion of the IL6ST and DDX4 genes. The fusion of the IL6ST and DDX4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IL6ST-DDX4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-RERE | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-REOR | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-REGO | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-REGR | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-REAQ | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-ORRE | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-OROR | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-ORGO | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-ORAQ | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GORE | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GOOR | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GOGO | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GOGR | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GOAQ | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GRRE | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GROR | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GRGO | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GRGR | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-GRAQ | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-AQRE | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-AQOR | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-AQGO | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-AQGR | 20 (40 μL) | 200 μL |
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| IL6ST-DDX4-20-AQAQ | 20 (40 μL) | 200 μL |
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IL6ST Gene Summary
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Gene Name: Interleukin 6 Signal Transducer
Chromosome: CHR5: 55230924 -55290821
Locus: 5q11.2
DDX4 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Name: DEAD-box Helicase 4
Chromosome: CHR5: 55033844 -55112974
Locus: 5q11.2
Gene Diseases
The IL6ST DDX4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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