ILF3-AP1M2 Fusion FISH Probe
The ILF3-AP1M2 Fusion FISH Probe is used to confirm a fusion of the ILF3 and AP1M2 genes. The fusion of the ILF3 and AP1M2 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ILF3-AP1M2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-RERE | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-REOR | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-REGO | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-REGR | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-REAQ | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-ORRE | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-OROR | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-ORGO | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GORE | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GOOR | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GOGO | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GOGR | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GRRE | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GROR | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GRGO | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GRGR | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-AQRE | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-AQOR | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-AQGO | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-AQGR | 20 (40 μL) | 200 μL |
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| ILF3-AP1M2-20-AQAQ | 20 (40 μL) | 200 μL |
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ILF3 Gene Summary
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
Gene Name: Interleukin Enhancer Binding Factor 3
Chromosome: CHR19: 10764936 -10803095
Locus: 19p13.2
AP1M2 Gene Summary
This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: Adaptor Related Protein Complex 1 Mu 2 Subunit
Chromosome: CHR19: 10683346 -10697991
Locus: 19p13.2
Gene Diseases
The ILF3 AP1M2 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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