ILF3-ATG4D Fusion FISH Probe
The ILF3-ATG4D Fusion FISH Probe is used to confirm a fusion of the ILF3 and ATG4D genes. The fusion of the ILF3 and ATG4D genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ILF3-ATG4D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-RERE | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-REOR | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-REGO | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-REGR | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-REAQ | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-ORRE | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-OROR | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-ORGO | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-ORAQ | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GORE | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GOOR | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GOGO | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GOGR | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GOAQ | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GRRE | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GROR | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GRGO | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GRGR | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-GRAQ | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-AQRE | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-AQOR | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-AQGO | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-AQGR | 20 (40 μL) | 200 μL |
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| ILF3-ATG4D-20-AQAQ | 20 (40 μL) | 200 μL |
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ILF3 Gene Summary
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
Gene Name: Interleukin Enhancer Binding Factor 3
Chromosome: CHR19: 10764936 -10803095
Locus: 19p13.2
ATG4D Gene Summary
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Autophagy Related 4D Cysteine Peptidase
Chromosome: CHR19: 10654646 -10664094
Locus: 19p13.2
Gene Diseases
The ILF3 ATG4D Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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