ILF3-PDE4A Fusion FISH Probe
The ILF3-PDE4A Fusion FISH Probe is used to confirm a fusion of the ILF3 and PDE4A genes. The fusion of the ILF3 and PDE4A genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ILF3-PDE4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-RERE | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-REOR | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-REGO | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-REGR | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-REAQ | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-ORRE | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-OROR | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-ORGO | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GORE | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GOOR | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GOGO | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GOGR | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GRRE | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GROR | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GRGO | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GRGR | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-AQRE | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-AQOR | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-AQGO | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-AQGR | 20 (40 μL) | 200 μL |
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| ILF3-PDE4A-20-AQAQ | 20 (40 μL) | 200 μL |
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ILF3 Gene Summary
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
Gene Name: Interleukin Enhancer Binding Factor 3
Chromosome: CHR19: 10764936 -10803095
Locus: 19p13.2
PDE4A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Gene Name: Phosphodiesterase 4A
Chromosome: CHR19: 10527448 -10580307
Locus: 19p13.2
Gene Diseases
The ILF3 PDE4A Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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