IMPA1-RSPO2 Fusion FISH Probe
The IMPA1-RSPO2 Fusion FISH Probe is used to confirm a fusion of the IMPA1 and RSPO2 genes. The fusion of the IMPA1 and RSPO2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IMPA1-RSPO2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-RERE | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-REOR | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-REGO | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-REGR | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-REAQ | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-ORRE | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-OROR | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-ORGO | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-ORAQ | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GORE | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GOOR | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GOGO | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GOGR | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GOAQ | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GRRE | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GROR | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GRGO | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GRGR | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-GRAQ | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-AQRE | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-AQOR | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-AQGO | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-AQGR | 20 (40 μL) | 200 μL |
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| IMPA1-RSPO2-20-AQAQ | 20 (40 μL) | 200 μL |
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IMPA1 Gene Summary
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Gene Name: Inositol Monophosphatase 1
Chromosome: CHR8: 82569150 -82598589
Locus: 8q21.13
RSPO2 Gene Summary
This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: R-spondin 2
Chromosome: CHR8: 108911543 -109095913
Locus: 8q23.1
Gene Diseases
The IMPA1 RSPO2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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