ING2-IDH1 Fusion FISH Probe
The ING2-IDH1 Fusion FISH Probe is used to confirm a fusion of the ING2 and IDH1 genes. The fusion of the ING2 and IDH1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ING2-IDH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-RERE | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-REOR | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-REGO | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-REGR | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-REAQ | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-ORRE | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-OROR | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-ORGO | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GORE | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GOOR | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GOGO | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GOGR | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GRRE | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GROR | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GRGO | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GRGR | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-AQRE | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-AQOR | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-AQGO | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-AQGR | 20 (40 μL) | 200 μL |
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| ING2-IDH1-20-AQAQ | 20 (40 μL) | 200 μL |
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IDH1 Gene Summary
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Name: Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic
Chromosome: CHR2: 209100952 -209119806
Locus: 2q34
ING2 Gene Summary
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Inhibitor Of Growth Family Member 2
Chromosome: CHR4: 184426219 -184432249
Locus: 4q35.1
Gene Diseases
The ING2 IDH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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