INPP5A-FRMD4A Fusion FISH Probe
The INPP5A-FRMD4A Fusion FISH Probe is used to confirm a fusion of the INPP5A and FRMD4A genes. The fusion of the INPP5A and FRMD4A genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INPP5A-FRMD4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-RERE | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-REOR | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-REGO | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-REGR | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-REAQ | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-ORRE | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-OROR | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-ORGO | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GORE | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GOOR | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GOGO | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GOGR | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GRRE | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GROR | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GRGO | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GRGR | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-AQRE | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-AQOR | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-AQGO | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-AQGR | 20 (40 μL) | 200 μL |
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| INPP5A-FRMD4A-20-AQAQ | 20 (40 μL) | 200 μL |
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INPP5A Gene Summary
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
Gene Name: Inositol Polyphosphate-5-phosphatase A
Chromosome: CHR10: 134351352 -134596984
Locus: 10q26.3
FRMD4A Gene Summary
This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: FERM Domain Containing 4A
Chromosome: CHR10: 13685705 -14372866
Locus: 10p13
Gene Diseases
The INPP5A FRMD4A Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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