INPP5D-GIGYF2 Fusion FISH Probe
The INPP5D-GIGYF2 Fusion FISH Probe is used to confirm a fusion of the INPP5D and GIGYF2 genes. The fusion of the INPP5D and GIGYF2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| INPP5D-GIGYF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| INPP5D-GIGYF2-20-AQAQ | 20 (40 μL) | 200 μL |
|
INPP5D Gene Summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: Inositol Polyphosphate-5-phosphatase D
Chromosome: CHR2: 233925035 -234116549
Locus: 2q37.1
GIGYF2 Gene Summary
This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: GRB10 Interacting GYF Protein 2
Chromosome: CHR2: 233562014 -233725289
Locus: 2q37.1
Gene Diseases
The INPP5D GIGYF2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|