INPP5K-RPA1 Fusion FISH Probe
The INPP5K-RPA1 Fusion FISH Probe is used to confirm a fusion of the INPP5K and RPA1 genes. The fusion of the INPP5K and RPA1 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INPP5K-RPA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-RERE | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-REOR | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-REGO | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-REGR | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-REAQ | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-ORRE | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-OROR | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-ORGO | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GORE | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GOOR | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GOGO | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GOGR | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GRRE | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GROR | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GRGO | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GRGR | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-AQRE | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-AQOR | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-AQGO | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-AQGR | 20 (40 μL) | 200 μL |
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| INPP5K-RPA1-20-AQAQ | 20 (40 μL) | 200 μL |
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RPA1 Gene Summary
This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]
Gene Name: Replication Protein A1
Chromosome: CHR17: 1733272 -1802848
Locus: 17p13.3
INPP5K Gene Summary
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Gene Name: Inositol Polyphosphate-5-phosphatase K
Chromosome: CHR17: 1397870 -1420182
Locus: 17p13.3
Gene Diseases
The INPP5K RPA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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