INTS12-CXXC4 Fusion FISH Probe
The INTS12-CXXC4 Fusion FISH Probe is used to confirm a fusion of the INTS12 and CXXC4 genes. The fusion of the INTS12 and CXXC4 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| INTS12-CXXC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-RERE | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-REOR | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-REGO | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-REGR | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-REAQ | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-ORRE | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-OROR | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-ORGO | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GORE | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GOOR | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GOGO | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GOGR | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GRRE | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GROR | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GRGO | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GRGR | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-AQRE | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-AQOR | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-AQGO | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-AQGR | 20 (40 μL) | 200 μL |
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| INTS12-CXXC4-20-AQAQ | 20 (40 μL) | 200 μL |
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INTS12 Gene Summary
INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Name: Integrator Complex Subunit 12
Chromosome: CHR4: 106603784 -106629881
Locus: 4q24
CXXC4 Gene Summary
This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Name: CXXC Finger Protein 4
Chromosome: CHR4: 105393342 -105412467
Locus: 4q24
Gene Diseases
The INTS12 CXXC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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