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ITM2B-CBS Fusion FISH Probe

The ITM2B-CBS Fusion FISH Probe is used to confirm a fusion of the ITM2B and CBS genes. The fusion of the ITM2B and CBS genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ITM2B-CBS-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ITM2B-CBS-20-RERE 20 (40 μL) 200 μL
ITM2B-CBS-20-REOR 20 (40 μL) 200 μL
ITM2B-CBS-20-REGO 20 (40 μL) 200 μL
ITM2B-CBS-20-REGR 20 (40 μL) 200 μL
ITM2B-CBS-20-REAQ 20 (40 μL) 200 μL
ITM2B-CBS-20-ORRE 20 (40 μL) 200 μL
ITM2B-CBS-20-OROR 20 (40 μL) 200 μL
ITM2B-CBS-20-ORGO 20 (40 μL) 200 μL
ITM2B-CBS-20-ORAQ 20 (40 μL) 200 μL
ITM2B-CBS-20-GORE 20 (40 μL) 200 μL
ITM2B-CBS-20-GOOR 20 (40 μL) 200 μL
ITM2B-CBS-20-GOGO 20 (40 μL) 200 μL
ITM2B-CBS-20-GOGR 20 (40 μL) 200 μL
ITM2B-CBS-20-GOAQ 20 (40 μL) 200 μL
ITM2B-CBS-20-GRRE 20 (40 μL) 200 μL
ITM2B-CBS-20-GROR 20 (40 μL) 200 μL
ITM2B-CBS-20-GRGO 20 (40 μL) 200 μL
ITM2B-CBS-20-GRGR 20 (40 μL) 200 μL
ITM2B-CBS-20-GRAQ 20 (40 μL) 200 μL
ITM2B-CBS-20-AQRE 20 (40 μL) 200 μL
ITM2B-CBS-20-AQOR 20 (40 μL) 200 μL
ITM2B-CBS-20-AQGO 20 (40 μL) 200 μL
ITM2B-CBS-20-AQGR 20 (40 μL) 200 μL
ITM2B-CBS-20-AQAQ 20 (40 μL) 200 μL

CBS Gene Summary

The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

Gene Name: Cystathionine-beta-synthase

Chromosome: CHR21: 44473300 -44496472

Locus: 21q22.3

ITM2B Gene Summary

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]

Gene Name: Integral Membrane Protein 2B

Chromosome: CHR13: 48807273 -48836232

Locus: 13q14.2

Gene Diseases

The ITM2B CBS Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.