ITPK1-ACO1 Fusion FISH Probe
The ITPK1-ACO1 Fusion FISH Probe is used to confirm a fusion of the ITPK1 and ACO1 genes. The fusion of the ITPK1 and ACO1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITPK1-ACO1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-RERE | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-REOR | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-REGO | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-REGR | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-REAQ | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-ORRE | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-OROR | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-ORGO | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GORE | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GOOR | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GOGO | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GOGR | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GRRE | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GROR | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GRGO | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GRGR | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-AQRE | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-AQOR | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-AQGO | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-AQGR | 20 (40 μL) | 200 μL |
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| ITPK1-ACO1-20-AQAQ | 20 (40 μL) | 200 μL |
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ACO1 Gene Summary
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
Gene Name: Aconitase 1
Chromosome: CHR9: 32384600 -32450832
Locus: 9p21.1
ITPK1 Gene Summary
This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]
Gene Name: Inositol-tetrakisphosphate 1-kinase
Chromosome: CHR14: 93403258 -93582263
Locus: 14q32.12
Gene Diseases
The ITPK1 ACO1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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