JAK1-HSD11B1 Fusion FISH Probe
The JAK1-HSD11B1 Fusion FISH Probe is used to confirm a fusion of the JAK1 and HSD11B1 genes. The fusion of the JAK1 and HSD11B1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JAK1-HSD11B1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-RERE | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-REOR | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-REGO | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-REGR | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-REAQ | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-ORRE | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-OROR | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-ORGO | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-ORAQ | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GORE | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GOOR | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GOGO | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GOGR | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GOAQ | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GRRE | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GROR | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GRGO | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GRGR | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-GRAQ | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-AQRE | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-AQOR | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-AQGO | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-AQGR | 20 (40 μL) | 200 μL |
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| JAK1-HSD11B1-20-AQAQ | 20 (40 μL) | 200 μL |
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HSD11B1 Gene Summary
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
Gene Name: Hydroxysteroid 11-beta Dehydrogenase 1
Chromosome: CHR1: 209859524 -209908295
Locus: 1q32.2
JAK1 Gene Summary
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: Janus Kinase 1
Chromosome: CHR1: 65298905 -65432187
Locus: 1p31.3
Gene Diseases
The JAK1 HSD11B1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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