JAK2-PKNOX2 Fusion FISH Probe
The JAK2-PKNOX2 Fusion FISH Probe is used to confirm a fusion of the JAK2 and PKNOX2 genes. The fusion of the JAK2 and PKNOX2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JAK2-PKNOX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-RERE | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-REOR | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-REGO | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-REGR | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-REAQ | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-ORRE | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-OROR | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-ORGO | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GORE | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GOOR | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GOGO | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GOGR | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GRRE | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GROR | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GRGO | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GRGR | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-AQRE | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-AQOR | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-AQGO | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-AQGR | 20 (40 μL) | 200 μL |
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| JAK2-PKNOX2-20-AQAQ | 20 (40 μL) | 200 μL |
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JAK2 Gene Summary
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
Gene Name: Janus Kinase 2
Chromosome: CHR9: 4985244 -5128183
Locus: 9p24.1
PKNOX2 Gene Summary
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
Gene Name: PBX/knotted 1 Homeobox 2
Chromosome: CHR11: 125034558 -125303285
Locus: 11q24.2
Gene Diseases
The JAK2 PKNOX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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