JARID2-BMP6 Fusion FISH Probe
The JARID2-BMP6 Fusion FISH Probe is used to confirm a fusion of the JARID2 and BMP6 genes. The fusion of the JARID2 and BMP6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JARID2-BMP6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-RERE | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-REOR | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-REGO | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-REGR | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-REAQ | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-ORRE | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-OROR | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-ORGO | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-ORAQ | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GORE | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GOOR | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GOGO | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GOGR | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GOAQ | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GRRE | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GROR | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GRGO | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GRGR | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-GRAQ | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-AQRE | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-AQOR | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-AQGO | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-AQGR | 20 (40 μL) | 200 μL |
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| JARID2-BMP6-20-AQAQ | 20 (40 μL) | 200 μL |
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BMP6 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]
Gene Name: Bone Morphogenetic Protein 6
Chromosome: CHR6: 7727010 -7881961
Locus: 6p24.3
JARID2 Gene Summary
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Gene Name: Jumonji And AT-rich Interaction Domain Containing 2
Chromosome: CHR6: 15246526 -15522253
Locus: 6p22.3
Gene Diseases
The JARID2 BMP6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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