JUP-EIF2AK2 Fusion FISH Probe
The JUP-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the JUP and EIF2AK2 genes. The fusion of the JUP and EIF2AK2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JUP-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| JUP-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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JUP Gene Summary
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
Gene Name: Junction Plakoglobin
Chromosome: CHR17: 39910858 -39942964
Locus: 17q21.2
EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
Gene Diseases
The JUP EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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