KANK1-NFX1 Fusion FISH Probe
The KANK1-NFX1 Fusion FISH Probe is used to confirm a fusion of the KANK1 and NFX1 genes. The fusion of the KANK1 and NFX1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KANK1-NFX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-RERE | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-REOR | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-REGO | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-REGR | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-REAQ | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-ORRE | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-OROR | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-ORGO | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GORE | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GOOR | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GOGO | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GOGR | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GRRE | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GROR | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GRGO | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GRGR | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-AQRE | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-AQOR | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-AQGO | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-AQGR | 20 (40 μL) | 200 μL |
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| KANK1-NFX1-20-AQAQ | 20 (40 μL) | 200 μL |
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NFX1 Gene Summary
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Transcription Factor, X-box Binding 1
Chromosome: CHR9: 33290417 -33371155
Locus: 9p13.3
KANK1 Gene Summary
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]
Gene Name: KN Motif And Ankyrin Repeat Domains 1
Chromosome: CHR9: 504702 -746103
Locus: 9p24.3
Gene Diseases
The KANK1 NFX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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