KCNAB2-KIF1B Fusion FISH Probe
The KCNAB2-KIF1B Fusion FISH Probe is used to confirm a fusion of the KCNAB2 and KIF1B genes. The fusion of the KCNAB2 and KIF1B genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KCNAB2-KIF1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-RERE | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-REOR | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-REGO | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-REGR | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-REAQ | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-ORRE | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-OROR | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-ORGO | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GORE | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GOOR | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GOGO | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GROR | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GRGR | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-AQRE | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-AQOR | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-AQGO | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-AQGR | 20 (40 μL) | 200 μL |
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| KCNAB2-KIF1B-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNAB2 Gene Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
Gene Name: Potassium Voltage-gated Channel Subfamily A Regulatory Beta Subunit 2
Chromosome: CHR1: 6052357 -6161253
Locus: 1p36.31
KIF1B Gene Summary
This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
Gene Name: Kinesin Family Member 1B
Chromosome: CHR1: 10270763 -10441661
Locus: 1p36.22
Gene Diseases
The KCNAB2 KIF1B Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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