KCNAB2-POLB Fusion FISH Probe
The KCNAB2-POLB Fusion FISH Probe is used to confirm a fusion of the KCNAB2 and POLB genes. The fusion of the KCNAB2 and POLB genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KCNAB2-POLB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-RERE | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-REOR | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-REGO | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-REGR | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-REAQ | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-ORRE | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-OROR | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-ORGO | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-ORAQ | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GORE | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GOOR | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GOGO | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GOAQ | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GROR | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GRGR | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-GRAQ | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-AQRE | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-AQOR | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-AQGO | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-AQGR | 20 (40 μL) | 200 μL |
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| KCNAB2-POLB-20-AQAQ | 20 (40 μL) | 200 μL |
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POLB Gene Summary
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Gene Name: DNA Polymerase Beta
Chromosome: CHR8: 42195972 -42229331
Locus: 8p11.21
KCNAB2 Gene Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
Gene Name: Potassium Voltage-gated Channel Subfamily A Regulatory Beta Subunit 2
Chromosome: CHR1: 6052357 -6161253
Locus: 1p36.31
Gene Diseases
The KCNAB2 POLB Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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