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KCNMB4-GDF3 Fusion FISH Probe

The KCNMB4-GDF3 Fusion FISH Probe is used to confirm a fusion of the KCNMB4 and GDF3 genes. The fusion of the KCNMB4 and GDF3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
KCNMB4-GDF3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
KCNMB4-GDF3-20-RERE 20 (40 μL) 200 μL
KCNMB4-GDF3-20-REOR 20 (40 μL) 200 μL
KCNMB4-GDF3-20-REGO 20 (40 μL) 200 μL
KCNMB4-GDF3-20-REGR 20 (40 μL) 200 μL
KCNMB4-GDF3-20-REAQ 20 (40 μL) 200 μL
KCNMB4-GDF3-20-ORRE 20 (40 μL) 200 μL
KCNMB4-GDF3-20-OROR 20 (40 μL) 200 μL
KCNMB4-GDF3-20-ORGO 20 (40 μL) 200 μL
KCNMB4-GDF3-20-ORAQ 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GORE 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GOOR 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GOGO 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GOGR 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GOAQ 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GRRE 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GROR 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GRGO 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GRGR 20 (40 μL) 200 μL
KCNMB4-GDF3-20-GRAQ 20 (40 μL) 200 μL
KCNMB4-GDF3-20-AQRE 20 (40 μL) 200 μL
KCNMB4-GDF3-20-AQOR 20 (40 μL) 200 μL
KCNMB4-GDF3-20-AQGO 20 (40 μL) 200 μL
KCNMB4-GDF3-20-AQGR 20 (40 μL) 200 μL
KCNMB4-GDF3-20-AQAQ 20 (40 μL) 200 μL

GDF3 Gene Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. [provided by RefSeq, Aug 2016]

Gene Name: Growth Differentiation Factor 3

Chromosome: CHR12: 7842380 -7848360

Locus: 12p13.31

KCNMB4 Gene Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]

Gene Name: Potassium Calcium-activated Channel Subfamily M Regulatory Beta Subunit 4

Chromosome: CHR12: 70760061 -70828072

Locus: 12q15

Gene Diseases

The KCNMB4 GDF3 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.