KCNN3-YEATS4 Fusion FISH Probe
The KCNN3-YEATS4 Fusion FISH Probe is used to confirm a fusion of the KCNN3 and YEATS4 genes. The fusion of the KCNN3 and YEATS4 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KCNN3-YEATS4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-RERE | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-REOR | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-REGO | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-REGR | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-REAQ | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-ORRE | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-OROR | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-ORGO | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-ORAQ | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GORE | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GOOR | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GOGO | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GOAQ | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GROR | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GRGR | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-GRAQ | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-AQRE | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-AQOR | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-AQGO | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-AQGR | 20 (40 μL) | 200 μL |
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| KCNN3-YEATS4-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNN3 Gene Summary
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Name: Potassium Calcium-activated Channel Subfamily N Member 3
Chromosome: CHR1: 154669941 -154842754
Locus: 1q21.3
YEATS4 Gene Summary
The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Name: YEATS Domain Containing 4
Chromosome: CHR12: 69753531 -69784576
Locus: 12q15
Gene Diseases
The KCNN3 YEATS4 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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